Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction.

Regio- and stereoselective synthesis of benzothiazolo-pyrimidinones via an NHC-catalyzed Mannich/lactamization domino reaction† †Electronic supplementary information (ESI) available. CCDC 1029497. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4cc08594a

Asymmetric synthesis of cyclopentanes bearing four contiguous stereocenters via an NHC-catalyzed Michael/Michael/esterification domino reaction† †Electronic supplementary information (ESI) available: Experimental procedures and characterization date (NMR, IR, MS, HPLC). CCDC 1437686. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc09581f Click here for additional data file. Click here for additional data file.

An NHC-catalyzed Michael/Michael/esterification domino reaction via homoenolate/enolate intermediates for the asymmetric synthesis of tetrasubstituted cyclopentanes bearing four contiguous stereocenters is described. A variety of α,β-unsaturated aldehydes and 2-nitroallylic acetates react well with good domino yields and high stereoselectivities.

A simple, solvent-free four-component domino synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives catalyzed by copper (II) oxide

An eco-safe and facile multi-component domino reaction has been described for the synthesis of 1H-pyrazolo [1, 2-b] phthalazine-5, 10-dione derivatives. The products were obtained by a four-component condensation reaction between phthalimide, hydrazine monohydrate, aromatic aldehyde derivatives and malononitrile in the presence of a catalytic amount of copper (II) oxide (CuO) ...

Stereoselective Synthesis of Pyrrolidinones via Nitro-Mannich Reaction Towards the Synthesis of Popolohuanone E

3 Acknowledgements 5 Abbreviations 6 Part 1: Stereoselective Synthesis of Pyrrolidinones via Nitro-Mannich Reaction

L-Proline catalyzed synthesis of Betti bases and biscoumarin derivatives

The direct three component modified Mannich reaction via condensation of aldehydes, 2-naphthol or 2,7-naphthalendiol and piperidine to generate Betti bases has been carried out over L-proline (20 mol%) with high efficiency under solvent free conditions at 70 OC. Also, the reaction of aromatic aldehyde and 4-hydroxycoumarin in the presence of L-proline (20 mol%) in the ethanol under reflux condi...